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Table 4 Effects of time varying obesity phenotypes and baseline covariates on the incidence of MI among males using the joint modelling approach

From: The effect of obesity phenotype changes on cardiovascular outcomes in adults older than 40 years in the prospective cohort of the Tehran lipids and glucose study (TLGS): joint model of longitudinal and time-to-event data

Male (2892)

MI from Bayesian Cox model

Obesity varying from Bayesian logit mixed effects model

Variables

 

Mean (SD)

HR (95% CI)

P-value

Mean (SD)

OR (95% CI)

P-value

Education (Reference: illiterate)

Literate

-0.31 (0.19)

0.73 (0.50 to 1.08)

0.12

-

-

-

Smoking status (Reference: Never smoker)

Past smoker

-0.10 (0.17)

0.90 (0.65 to 1.24)

0.55

-0.43 (0.22)

0.65 (0.42 to 0.99)

0.05

 

Current smoker

0.22 (0.17)

1.24 (0.90 to 1.75)

0.19

-1.30 (0.19)

0.27 (0.18 to 0.40)

<0.001

Physical activity (Reference: Highest)

Lowest

0.02 (0.12)

1.02 (0.79 to 1.29)

0.84

0.49 (0.16)

1.63 (1.18 to 2.27)

0.002

Family history of diabetes (Reference: No)

Yes

-0.18 (0.14)

0.83 (0.62 to 1.09)

0.21

-

-

-

Family history of CVD (Reference: No)

Yes

-0.13 (0.18)

0.87 (0.61 to 1.23)

0.48

-

-

-

Obesity phenotypes (Reference: Normal)

Abnormal

-0.45 (0.39)

0.63 (0.28 to 1.35)

0.24

-

-

-

Age (year)

 

0.08 (0.21)

1.08 (0.79 to 1.69)

0.87

0.01 (0.01)

1.01 (0.99 to 1.03)

0.13

The associations of study variables with incidence of MI among females using survival and longitudinal models

Female (3458)

MI from Bayesian Cox model

Obesity varying from Bayesian logit mixed effects model

Variables

 

HR (95% CI)

P-value

OR (95% CI)

P-value

Education (Reference: illiterate)

Literate

0.71 (0.48 to 1.04)

0.08

-

-

Smoking status (Reference: Never smoker)

Past smoker

0.85 (0.27 to 2.68)

0.78

1.15 (0.29 to 4.60)

0.83

 

Current smoker

1.23 (0.39 to 3.89)

0.71

0.44 (0.16 to 1.15)

0.09

Physical activity (Reference: Highest)

Lowest

1.001 (0.70 to 1.41)

0.99

1.05 (0.70 to 1.56)

0.80

Family history of diabetes (Reference: No)

Yes

1.81 (1.29 to 2.54)

<0.001

-

-

Family history of CVD (Reference: No)

Yes

1.35 (0.91 to 2.01)

0.13

-

-

Obesity phenotypes (Reference: Normal)

Abnormal

2.56 (0.94 to 6.91)

0.06

-

-

Age (year)

 

1.08 (1.06 to 1.10)

<0.001

1.15 (1.13 to 1.71)

<0.001

  1. α: association between survival model and longitudinal model, p-value<0.001
  2. Abbreviations CVD: cardiovascular disease; SD: standard deviation; HR: hazard ratio; OR: odds ratio; CI: credible interval