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Table 4 Additive interaction between family history of diabetes and hypertension on the diagnosis of diabetes among individuals aged 45 and above

From: Additive interaction of family medical history of diabetes with hypertension on the diagnosis of diabetes among older adults in India: longitudinal ageing study in India

 

Model 1 (Unadjusted)

Model 2 (Adjusted)

(1) Self-reported Diabetes

(A) Self-reported HT

Additive Interaction between family history and hypertension

0.FH#0.hypertension

Ref.

Ref.

0.FH#1.hypertension

5.93*** (5.25 6.70)

4.21*** (3.71 4.79)

1.FH#0.hypertension

4.00*** (3.37 4.78)

2.82*** (2.25 3.50)

1.FH#1.hypertension

17.63*** (13.13 23.68)

9.28*** (7.51 11.46)

Measures of interaction on the additive scale (P-value, 95% CI)

RERI

8.69; 0.001 (3.61 13.77)

3.5; 0.001 (1.52 5.47)

AP$

0.49; 0.000 (0.34 0.64)

0.37; 0.000 (0.22 0.51)

S

2.09; 0.000 (1.53 2.87)

1.69; 0.000 (1.31 2.18)

(B)Self-reported HT - taking medication

Additive Interaction between family history and hypertension (taking medication)

0.FH#0.HTM

Ref.

Ref.

0.FH#1.HTM

6.34*** (5.60 7.18)

4.07*** (3.57 4.64)

1.FH#0.HTM

3.55*** (3.03 4.15)

2.60*** (2.14 3.16)

1.FH#1.HTM

19.57*** (14.12 27.12)

9.46*** (7.46 12.00)

Measures of interaction on the additive scale (P-value, 95% CI)

RERI

10.68; 0.001 (4.37 17.01)

3.79; 0.000 (1.58 6.01)

AP$

0.55; 0.000 (0.40 0.70)

0.40; 0.000 (0.25 0.55)

S

2.35; 0.000 (1.66 3.34)

1.81; 0.000 (1.37 2.40)

 

Model 1 (Unadjusted)

Model 2 (Adjusted)

(2) Self-reported diabetes, currently on medication

(A) Self-reported HT

Additive Interaction between family history and hypertension

0.FH#0.hypertension

Ref.

Ref.

0.FH#1.hypertension

5.56*** (4.83 6.40)

3.73*** (3.23 4.31)

1.FH#0.hypertension

3.92*** (3.26 4.72)

2.53*** (1.98 3.23)

1.FH#1.hypertension

18.11*** (13.10 25.04)

8.50*** (6.82 10.61)

Measures of interaction on the additive scale (P-value, 95% CI)

RERI

8.68; 0.001 (3.61 13.75)

3.24; 0.000 (1.46 5.03)

AP$

0.49; 0.000 (0.34 0.64)

0.38; 0.000 (0.24 0.52)

S

2.09; 0.000 (1.53 2.87)

1.76; 0.000 (1.34 2.30)

(B)Self-reported HT - taking medication

Additive Interaction between family history and hypertension (taking medication)

0.FH#0.HTM

Ref.

Ref.

0.FH#1.HTM

7.58*** (6.58 8.73)

4.74*** (4.08 5.49)

1.FH#0.HTM

3.65*** (3.07 4.33)

2.46*** (1.98 3.07)

1.FH#1.HTM

24.73*** (17.55 34.84)

11.11*** (8.72 14.17)

Measures of interaction on the additive scale (P-value, 95% CI)

RERI

14.50; 0.001 (6.18 22.81)

4.91; 0.000 (2.33 7.49)

AP$

0.59; 0.000 (0.44 0.73)

0.44; 0.000 (0.30 0.58)

S

2.57; 0.000 (1.79 3.68)

1.94; 0.000 (1.47 2.56)

  1. *p < 0.05, **p < 0.01; ***p < 0.001; Ref, reference category; FH, family medical history of diabetes; HT, hypertension; HTM, hypertensive individuals who were on medication
  2. Interaction exists if RERI!= 0 or AP!= 0 or S!= 1
  3. Model 1: Unadjusted model; Model 2: Adjusted for age, sex, education, working, marital status, residence, MPCE, religion, caste, region, physical inactivity, smoking, chewing tobacco, alcohol consumption, and body mass index (BMI), ADL, IADL, high cholesterol
  4. RERI, Relative excess risk due to interaction; AP, Attributable proportion; AP$, the attributable proportion, has been presented in the result as a percentage after multiplied by 100; S, Synergy index
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BMC Public Health

ISSN: 1471-2458

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