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Table 2 Baseline and follow-up changes in physiological markers and disease risk predictions following 12-week intervention in participants who completed both the baseline and follow-up testing only

From: Evaluating differences in the clinical impact of a free online weight loss programme, a resource-intensive commercial weight loss programme and an active control condition: a parallel randomised controlled trial

  

HWP

NHS

GYM

Δ Change

Baseline ± SD

Follow-up ± SD

Baseline ± SD

Follow-up ± SD

Baseline ± SD

Follow-up ± SD

Time

Time x Intervention

Anthropometrics

Body Mass (kg)

106.38 ± 14.90

101.21 ± 14.16

103.13 ± 16.92

98.94 ± 16.97

98.98 ± 13.54

97.81 ± 12.61

< 0.001

< 0.01

Body Mass Index (kg.m2)

35.86 ± 3.41

34.16 ± 3.73

35.25 ± 3.51

33.82 ± 3.86

34.85 ± 2.97

34.50 ± 3.20

< 0.01

< 0.05

Waist Circumference (cm)

108.6 ± 12.3

101.9 ± 8.8

107.2 ± 12.0

96.4 ± 12.2

104.9 ± 10.2

98.2 ± 11.3

< 0.001

NS

Hip Circumference (cm)

119.5 ± 10.2

114.6 ± 9.9

119.0 ± 10.3

113.7 ± 11.0

117.8 ± 6.2

115.0 ± 7.5

< 0.001

NS

Body Fat (%)

40.9 ± 9.1

39.4 ± 8.9

39.4 ± 8.9

39.2 ± 7.5

40.3 ± 7.7

40.2 ± 7.9

NS

NS

Body Fat (kg)

43.1 ± 9.3

39.4 ± 10.0

40.5 ± 11.1

38.7 ± 9.9

39.8 ± 9.0

39.2 ± 9.3

NS

NS

Fat Free Mass (kg)

63.3 ± 15.1

60.5 ± 12.8

62.1 ± 14.6

60.4 ± 13.5

59.4 ± 12.3

58.2 ± 10.9

< 0.01

NS

Hemodynamics

Systolic Blood Pressure (mmHg)

138 ± 19

134 ± 14

129 ± 12

129 ± 11

129 ± 11

130 ± 8

NS

NS

Diastolic Blood Pressure (mmHg)

91 ± 12

87 ± 8

82 ± 7

82 ± 8

81 ± 7

82 ± 7

NS

NS

Mean Arterial Pressure (mmHg)

106 ± 14

104 ± 10

98 ± 8

99 ± 9

97 ± 7

97 ± 11

NS

NS

Resting Heart Rate (beat/min)

70 ± 10

70 ± 9

70 ± 11

68 ± 9

68 ± 8

65 ± 9

NS

NS

Hematology

Fasting Blood Glucose (mmol/L)

5.27 ± 0.66

5.20 ± 1.09

5.20 ± 0.51

4.76 ± 0.59

5.08 ± 0.50

4.90 ± 0.39

< 0.05

NS

Insulin (mlU/L)

16 ± 24

10 ± 6

10 ± 6

8 ± 4

20 ± 47

9 ± 5

NS

NS

HOMA-Insulin Resistance (au)

3.8 ± 5.2

2.3 ± 1.2

2.4 ± 1.6

1.8 ± 1.0

5.0 ± 11.6

4.7 ± 11.6

NS

NS

Triglycerides (mmol/L)

2.14 ± 1.49

1.68 ± 0.99

1.84 ± 1.22

1.4 ± 0.8

1.47 ± 0.87

1.40 ± 1.05

0.01

NS

Total Cholesterol (mmol/L)

5.29 ± 0.84

4.89 ± 1.03

5.43 ± 0.80

5.13 ± 0.74

5.00 ± 1.07

5.07 ± 1.46

NS

NS

HDL-Cholesterol (mmol/L)

1.28 ± 0.30

1.31 ± 0.28

1.39 ± 0.40

1.49 ± 0.42

1.31 ± 0.36

1.38 ± 0.33

< 0.001

NS

Total: HDL Cholesterol Ratio

4.4 ± 1.5

3.9 ± 1.2

4.3 ± 1.6

3.8 ± 1.3

4.0 ± 1.3

4.0 ± 2.1

< 0.05

NS

LDL-Cholesterol (mmol/L)

3.31 ± 1.03

2.92 ± 0.95

3.26 ± 0.68

3.07 ± 0.77

3.08 ± 1.12

3.00 ± 1.02

< 0.01

NS

HbA1C DCCT (%)

5.4 ± 0.7

5.2 ± 0.4

5.2 ± 0.4

5.1 ± 0.2

5.1 ± 0.3

5.1 ± 0.3

< 0.05

NS

Hba1C IFCC (mmol/mol)

36 ± 7

33 ± 4

33 ± 4

32 ± 2

32 ± 4

33 ± 4

< 0.05

NS

Disease Risk

QRISK2 Prediction (%)

2.8 ± 2.0

2.3 ± 1.7

1.5 ± 1.5

1.3 ± 1.4

1.3 ± 1.1

1.3 ± 1.1

0.001

NS

QDiabetes Risk Prediction (%)

8.4 ± 5.3

7.2 ± 4.7

5.6 ± 5.1

6.6 ± 11.2

5.0 ± 4.1

4.6 ± 3.9

NS

NS

  1. Bold denotes significant main effect of time. Δ Change (p-Value) refers to difference between pre and post intervention for all groups (time). N = 18, 21 and 24 for HWP, NHS and GYM respectively. NS denotes Non-significant. Significance accepted as p < 0.05