E-cigarette puffing patterns associated with high and low nicotine e-liquid strength: effects on toxicant and carcinogen exposure

Table 1 Provides a summary of participant and data collection timeline

	Study period
	Enrolment	Allocation	Post-allocation					Close-out
Timepoint	-t ₁	0	t ₀	t ₁	t ₂	t ₃	t ₄	t _x
Enrolment:
Eligibility screen	X
Informed consent	X
Allocation		X
Intervention:
Fixed-user setting (6mg/mL nicotine or 18mg/mL)				X	X
Fixed-user setting (6mg/mL nicotine or 18mg/mL)						X	X
Assessments:
Demographics (e.g. age, gender, ethnic group, educational qualification)	X		X
Vaping and previous smoking history	X		X
Breath carbon monoxide (CO) sample			X	X	X	X	X
Puffing behaviour and participant reports				X	X	X	X
Mood and Physical Symptoms Scale (MPSS) to record withdrawal symptoms			X	X	X	X	X
Urge to vape			X	X	X	X	X
Saliva sample			X	X	X	X	X
Urine sample			X	X	X	X	X
Adverse events			X	X	X	X	X
Participant feedback								X
Debrief								X

ISSN: 1471-2458