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Table 1 Patients’ characteristics at enrolment according to cancer-categories

From: Cancer incidence and mortality for all causes in HIV-infected patients over a quarter century: a multicentre cohort study

Variables

Categories

Total

ADC

NADC

Without cancer

P value

Total

 

16268

688

471

15109

 

Gender

Male

12116 (74.5)

549 (79.8)

360 (76.4)

11207 (74.2)

0.003

Female

4152 (25.5)

139 (20.2)

111 (23.6)

3902 (25.8)

 

Age at enrolment (years)

18-34

9797 (60.2)

369 (53.6)

228 (48.4)

9200 (20.9)

<0.001

35-44

4278 (26.3)

189 (27.5)

121 (25.7)

3968 (26.3)

 

45-54

1538 (9.5)

91 (13.2)

71 (15.1)

1376 (9.1)

 
 

55-64

513 (3.1)

36 (5.2)

41 (8.7)

436 (2.9)

 
 

>65

142 (0.9)

3 (0.4)

10 (2.1)

129 (1.0)

 
 

Mean (SD)

34.2 (9.8)

35.6 (10.3)

37.8 (11.9)

34.1 (9.7)

<0.001

Year of enrolment

1986-1989

2275 (14.0)

79 (16.8)

135 (19.6)

2061 (13.6)

<0.001

 

1990-1993

2835 (17.4)

99 (21.0)

121 (17.6)

2615 (17.3)

 
 

1994-1997

2465 (15.1)

98 (20.8)

137 (19.9)

2230 (14.8)

 
 

1998-2001

2522 (15.5)

73 (15.5)

101 (14.7)

2348 (15.5)

 
 

2002-2005

2539 (15.6)

70 (14.9)

108 (15.7)

2361 (15.6)

 
 

2006-2012

3632 (22.3)

52 (11.0)

86 (12.5)

3494 (23.1)

 

IDUs

No

8374 (51.5)

363 (52.8)

200 (42.5)

7811 (51.7)

<0.001

 

Yes

7894 (48.5)

325 (47.2)

271 (57.5)

7298 (48.3)

 

HBV/HCV co-infection

No

8374 (51.5)

363 (52.8)

200 (42.5)

7811 (51.7)

<0.001

 

Yes

7894 (48.5)

325 (47.2)

271 (57.5)

7298 (48.3)

 

CD4 cell count , cell/mm3

0-49

1151 (7.1)

95 (13.8)

28 (5.9)

1028 (6.8)

<0.001

50-99

940 (5.8)

59 (8.6)

31 (6.6)

850 (5.6)

 
 

100-199

2038 (12.5)

136 (19.8)

70 (14.9)

1832 (12.1)

 

200-349

3464 (21.3)

144 (20.9)

100 (21.2)

3220 (21.3)

 

350-499

3346 (20.6)

110 (16.0)

107 (22.7)

3129 (20.7)

 

≥500

5329 (32.8)

144 (20.9)

135 (28.7)

5050 (33.4)

 
 

Mean (SD)

416.8 (298.6)

316.7 (272.6)

401.8 (300.8)

421.8 (298.9)

<0.001

Log10 HIVRNA, copies/mL

Mean (SD)

3.1 (1.4)

3.3 (1.5)

3.0 (1.4)

3.1 (1.4)

NS

Treatment-naïve

No

14179 (87.2)

610 (88.7)

412 (87.5)

13157 (87.1)

NS

 

Yes

2089 (12.8)

78 (11.3)

59 (12.5)

1952 (12.9)

 
  1. Patients with both ADC and NADC diagnosis (n = 36) were considered as ADC or NADC on the basis of which first occurred cancer.
  2. Abbreviations: ADC AIDS-defining-cancer, NADC non-AIDS-defining-cancer, SD standard deviation, NS not statistically significant (p > 0.05), IDUs intravenous drug users, HBV/HCV co-infection hepatitis B virus/hepatitis C virus positivity.