Nicotine dependence in an isolated population of Kashubians from North Poland: a population survey

BMC Public Health

Table 4 Logistic regression results for the association between smoking more than 20 cigarettes per day and selected polymorphisms

SNP/Genotype	FTND No. of subjects		OR(95% CI)p-value	CPD* No. of subjects		OR (95% CI) p-value	HSI No. of subjects		OR (95% CI)p-value	TTF No. of subjects		OR (95% CI) p-value
SNP/Genotype	<4	≥4	OR(95% CI)p-value	≤20	>20	OR (95% CI) p-value	<3	≥3	OR (95% CI)p-value	≤5 min	>5 min	OR (95% CI) p-value
rs16969968 at CHRNA5/
GG	218	252	1	397	44	1	251	219	1	103	367	1
AA + AG	222	277	1.08 (0.83-1.40) 0.56	391	70	1.63 (1.09-2.45) 0.017**	251	248	1.13 (0.88-1.46) 0.33	127	372	1.22 (0.91-1.65) 0.19
rs578776 at CHRNA3/
CC	232	269	1	403	62	1	264	237	1	119	382	1
TT + TC	208	260	1.09 (0.84-1.41) 0.52	385	52	0.89 (0.60-1.30) 0.56	238	230	1.08 (0.84-1.39) 0.55	111	357	0.99 (0.73-1.33) 0.94
rs12914008 at CHRNB4/
GG	398	485	1	717	105	1	455	428	1	209	674	1
AA + AG	42	44	0.86 (0.55-1.35) 0.52	71	9	0.87 (0.42-1.80) `0.70	47	39	0.88 (0.57-1.38) `0.58	21	65	1.04 (0.61-1.77) 0.90

*Only daily smokers.
**A rounded down p-value. The exact p-value is 0.01756.
The values in boldface denote the suggestive association when applying Bonferroni correction procedure for multiple testing (significance level: p = 0.017).
ORs are adjusted for age, sex and remaining polymorphisms.

ISSN: 1471-2458