Assessing health and economic outcomes of interventions to reduce pregnancy-related mortality in Nigeria

BMC Public Health

Table 6 Assessing uncertainty of several biological and nonbiological input parameters

Analysis	Predicted reduction in maternal deaths	Cost effectiveness ratios (per year of life saved)
Unchanged parameters (i.e. incidences, CFR and effectiveness)	6% - 65%	6.3 - 10.5
Reduced incidences of direct maternal complications	5% - 62%	6.2 - 9.8
Increased incidence of direct maternal complications	6% - 66%	6.4 - 12.0
Reduced CFR of direct maternal complications	6% - 66%	6.3 -10.5
Increased CFR of direct maternal complications	5% - 65%	6.3 - 10.5
Reduced effectiveness of maternal interventions	5% - 58%	6.3 - 10.5
Increased effectiveness of maternal interventions	7% - 72%	6.3 - 10.5
Reduced costs of maternal interventions	6% - 65%	4.2 – 8.4
Increased costs of maternal interventions	6% - 65%	10.4 – 15.1

Estimates used in the sensitivity analysis are as follows: postpartum hemorrhage [reduced incidence = 0.051; increased incidence = 0.228; reduced CFR = 0.007; increased CFR = 0.03; reduced effectiveness of interventions = 60%; increased effectiveness of interventions = 90%], obstructed labor [reduced incidence = 0.03; increased incidence = 0.074; reduced CFR = 0.005; increased CFR = 0.025; reduced effectiveness of interventions = 76%; increased effectiveness of interventions = 100%], hypertensive disorders of pregnancy [reduced incidence = 0.025; increased incidence = 0.05; reduced CFR = 0.012; increased CFR = 0.027; reduced effectiveness of interventions = 45%; increased effectiveness of interventions = 95%], Sepsis [reduced incidence = 0.043; increased incidence = 0.06; reduced CFR = 0.009; increased CFR = 0.036; reduced effectiveness of interventions = 63%; increased effectiveness of interventions = 93%]. Additional findings are contained in the Additional file 1.

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