Dependent variables | Time period | Factored ARIMA model* | Independent variables† | Coefficients‡ | p value |
---|---|---|---|---|---|
Primary analyses | |||||
ACEIs | Jan 1997 to Dec 2008 | p = (6); | Constant | 232,380 | <0.0001 |
q = (6)(12) | Baseline trend | 5,531 | <0.0001 | ||
PA2000 level change | -48,286 | <0.0001 | |||
PA2004 level change | 28,987 | 0.0073 | |||
PA2004 trend change | -4,860 | <0.0001 | |||
PA2006 trend change | -3,529 | 0.0002 | |||
CNY | -36,256 | <0.0001 | |||
ARB | Feb 1998 to Dec 2008 | p = (2,3)(12) | Baseline trend | 5,044 | <0.0001 |
PA2003 trend change | 5,014 | <0.0001 | |||
PA2007 trend change | 8,583 | 0.0003 | |||
CNY | -21,476 | 0.0219 | |||
Renin-angiotensin drugs | Jan 1997 to Dec 2008 | p = (2,5)(12) | Constant | 135,289 | <0.0001 |
Baseline trend | 12,027 | <0.0001 | |||
PA2000 level change | -73,794 | 0.0053 | |||
CNY | -32,789 | 0.0371 | |||
Subgroup analyses for ACEIs | |||||
Patented ACEIs | Jan 1997 to Dec 2008 | p = (6); | Constant | 18,039 | <0.0001 |
q = (6) | Baseline trend | 872 | <0.0001 | ||
PA2000 level change | -9,466 | <0.0001 | |||
PA2001 level change | 6,416 | 0.0022 | |||
PA2004 trend change | 1,235 | <0.0001 | |||
PA2005 level change | -13,602 | <0.0001 | |||
CNY | -7,318 | <0.0001 | |||
Off-patent ACEIs | Jan 1997 to Dec 2008 | p = (12); | Constant | 209,374 | <0.0001 |
q = (9) | Baseline trend | 4,617 | <0.0001 | ||
PA2000 level change | -37,219 | <0.0001 | |||
PA2004 level change | 26,145 | 0.0028 | |||
PA2004 trend change | -5,201 | <0.0001 | |||
PA2006 trend change | -4,593 | <0.0001 | |||
CNY | -20,665 | 0.0021 | |||
Off-patent original branded ACEIs | Jan 1997 to Dec2008 | p = (1,4,5)(12) | Constant | 179,478 | <0.0001 |
Baseline trend | 527 | 0.0081 | |||
PA2000 level change | -21,380 | 0.0031 | |||
PA2004 trend change | -2,574 | <0.0001 | |||
CNY | -11,501 | 0.0003 | |||
Off-patent generic ACEIs | Jan 1997 to Dec 2008 | p = (12); | Constant | 25,416 | <0.0001 |
q = (12) | Baseline trend | 4,205 | <0.0001 | ||
PA2000 level change | -23,138 | <0.0001 | |||
PA2004 level change | 22,925 | <0.0001 | |||
PA2005 trend change | -4,315 | <0.0001 | |||
PA2006 trend change | -3,197 | <0.0001 | |||
CNY | -9,447 | 0.0445 |