From: Effect of case management on neonatal mortality due to sepsis and pneumonia
Effect on neonatal deaths due to pneumonia | |
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Cause specific effect and 95% CI/ interquartile range: | |
Oral therapy | 42% (18-59%,95% CI) |
Injection therapy | 75% (70-81% interquartile range on Delphi) |
Hospital-based case management | 90% (89-95% interquartile range on Delphi) |
Quality of input evidence: | |
For oral therapy, moderate (3 low quality non-randomized concurrent control studies) | |
For the effects of injection therapy and full case management, the level of evidence is very low (based on Delphi). | |
Proximity of the data to cause specific mortality effect: | |
Moderate for oral therapy as several low quality but consistent studies; however, lack of consistency in cause-of-death definitions | |
Very low quality for injection therapy and full case management as these results are based on Delphi | |
Limitations of the evidence: | |
Interpretation of the data is limited by concurrent interventions particularly for studies with injection case management | |
Possible adverse effects: | |
Data not reviewed | |
Effect on neonatal deaths due to sepsis and meningitis | |
Cause specific effect and interquartile range: | |
Oral therapy | 28% (20-36.25% interquartile range on Delphi) |
Injection therapy | 65% (50-70% interquartile range on Delphi) |
Hospital-based management | 80% (75-85% interquartile range on Delphi) |
Quality of input evidence: | |
Very low (based on Delphi) | |
Proximity of the data to cause specific mortality effect: | |
Direct effect estimated by Delphi | |
Limitations of the evidence: | |
Lack of direct evidence on sepsis-specific mortality. Studies have evaluated injectable antibiotics as part of multiple co-intervention peri-natal care packages. | |
Possible adverse effects: | |
Data not reviewed |