Exploring the effect of biological delays in kinetic models of influenza within a host or cell culture

BMC Public Health

Table 1 Information on the individual single-cycle viral yield experiments plotted in Figure 3

(Label) Strain	Cell Type	MOI^a	VU^b	p* (VU/h)	(h)	ref.
(A) A/Udorn/307/72 (H3N2)	A549	3	PFU/mL	(8.2 ± 0.3) × 10⁵	10.9 ± 0.8	[28]
(B) A/Udorn/307/72 (H3N2)^c	A549	3	PFU/mL	(2.7 ± 0.6) × 10⁵	12 ± 5	[28]
(C) A/Udorn/307/72 (H3N2)	A549	5	PFU/mL	(3.1 ± 0.9) × 10⁶	(6 ± 3)	[29]
(D) A/Udorn/307/72 (H3N2)^d	A549	5	PFU/mL	(2.6 ± 0.1) × 10⁶	5.8 ± 0.4	[29]
(E) A/Udorn/307/72 (H3N2)	MDCK	5	PFU/mL	(5.6 ± 0.3) × 10⁶	(6.1 ± 0.4)	[29]
(F) A/PR/8/34 (H1N1)	MDCK	10	TCID₅₀/mL	(4 ± 1) × 10³	6 ± 3	[30]
(G) A/PR/8/34 (H1N1)	MDCK	32	PFU	(7.5 ± 0.4) × 10⁵	(9.8 ± 1)	[9]
(H) A/X-31 (H3N2)	Vera	50	TCID₅₀/mL	(1.34 ± 0.01) × 10⁶	(3.75 ± 0.01)	[31]
(I) A/NWS/33 (H1N1)	1-5C-4	50	PFU/mL	(1.26 ± 0.07) × 10⁵	10.8 ± 1	[32]

a — The number of cells used in each experiment was ~ 2 × 10⁶ except for (F) and (G) which had 9 × 10⁶ and 3 × 10⁵cells, respectively.
b — Virus Unit. It should be noted that this unit is inherently experiment-specific, depending on virus strain, cell type and experimental details. Quantities which depend on VU (e.g., p*) cannot be directly compared between experimental groups.
c — NS1-T215A recombinant mutant.
d — NS1-R38A recombinant mutant.

ISSN: 1471-2458