Epidemiology of anti-tuberculosis drug resistance in a chinese population: current situation and challenges ahead

BMC Public Health

Table 4 Factors associated with multi-drug resistant tuberculosis

Factors	Cases	No-MDR^†	MDR^†	cOR(95% CI) ^‡	P	aOR(95% CI) *	P
	n = 1824	n = 1521, n(%)	n = 303, n(%)
Sex
Men	1340	1129(84.25)	211(15.75)	1		1
Women	484	392(80.99)	92(19.01)	1.26(0.96-1.65)	0.099	1.43(0.99-2.06)	0.058
Age (years)
65+	547	465(85.01)	82(14.99)	1		1
55-64	298	247(82.89)	51(17.11)	1.17(0.80-1.72)	0.418	1.11(0.74-1.67)	0.602
45-54	276	217(78.62)	59(21.38)	1.54(1.06-2.24)	0.022	1.53(1.03-2.28)	0.035
35-44	270	208(77.04)	62(22.96)	1.69(1.17-2.44)	0.005	1.88(1.26-2.81)	0.002
25-34	188	169(89.89)	19(10.11)	0.64(0.38-1.08)	0.095	0.87(0.49-1.53)	0.626
< 25	245	215(87.76)	30(12.24)	0.79(0.51-1.24)	0.306	1.38(0.84-2.29)	0.206
Treatment history ^#
No	1180	1090(92.37)	90(7.63)	1		1
Yes	644	431(66.93)	213(33.07)	5.99(4.57-7.84)	< 0.001	6.14(4.61-8.17)	< 0.001
Area of residence
South	718	623(86.77)	95(13.23)	1		1
Central	343	280(81.63)	63(18.37)	1.48(1.04-2.09)	0.029	1.47(1.01-2.13)	0.044
North	763	618(81.00)	145(19.00)	1.54(1.16-2.04)	0.003	1.42(1.05-1.92)	0.023
Cigarette smoking ^&
Never	862	706(81.90)	156(18.10)	1		1
Ever	954	809(84.80)	145(15.20)	0.81(0.63-1.04)	0.098	1.01(0.72-1.42)	0.942

†:MDR, multidrug-resistant, resistance to at least isoniazid and rifampicin; ‡: cOR, crude odds ratio; *aOR, adjusted odds ratio, adjusted for sex, age, treatment history, area and cigarette smoking; #:Those having previously received anti-tuberculosis treatment for more than one month was defined as previously treated cases; &: 8 cases with missing value.

ISSN: 1471-2458