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Table 4 Scenario analyses: optimal combination of Wolbachia and paediatric dengue vaccination coverage to minimize the number of dengue cases (and DALYs lost) – base-case budget constraint

From: Reducing dengue fever cases at the lowest budget: a constrained optimization approach applied to Thailand

Scenario

Wolbachia (%)

Paediatric vaccination (%)

Cases (millions)

DALYs lost

Total costs (PP) ($millions)

Wolbachia cost (lower bounds)

100

71

1.073

10,143

368.820

Vaccine cost −50%

43

100

1.075

10,167

367.215

Unit cost profile [59]

45

64

1.161

10,979

368.916

80% vaccine efficacy

44

53

1.180

11,158

368.389

Societal perspective

51

43

1.206

11,399

368.846

Vaccine coverage 70–100%

22

70

1.216

11,500

368.680

50% vaccine efficacy

69

33

1.221

11,540

368.630

Vaccine cost + 50%

68

23

1.230

11,628

368.925

Wolbachia cost (upper bounds)

21

41

1.326

12,531

366.220

5-year follow-up

33

22

1.317

12,450

202.720

  1. DALY disability-adjusted life year, PP payer perspective