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Table 3 Optimal combination of Wolbachia and paediatric dengue vaccination coverage to minimize the number of dengue cases (and DALYs lost) by budget constraint

From: Reducing dengue fever cases at the lowest budget: a constrained optimization approach applied to Thailand

Budget constraint ($ millions) Wolbachia (%) Paediatric vaccination (%) Cases (millions) DALYs lost Wolbachia costs ($ millions) Vaccination costs ($ millions) Total costs (PP) ($ millions)
Steady state 0 0 7.175 67,831 $337.830a
≥ 590 100 100 1.022 9660 273.744 350.666 $678.674
≤ 589 67 100 1.046 9888 182.496 350.666 $588.677
≤ 368 50 49 1.194 11,288 135.489 170.020 $368.772
≤ 251 54 10 1.296 12,256 147.854 25.331 $251.601
  1. Bold text indicates steady state estimates without control
  2. DALY disability-adjusted life year, PP payer perspective
  3. a$414 million from a societal perspective