One-time screening at age | Interval screening at age 55–59, with interval | Interval screening at age 55–64, with interval | Interval screening at age 55–69, with interval | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
55y | 59y | 64y | 69y | 4y (2 x) | 2y (3 x) | 1y (5 x) | 4y (3 x) | 2y (5 x) | 1y (10 x) | 4y (4 x) | 2y (8 x) | 1y (15 x) | |
Predictions for men average PCa risk | |||||||||||||
Base-case result | −1.3 | −2.3 | −3.9 | −7.2 | −2.8 | −3.5 | −4.4 | −4.9 | −5.8 | −6.7 | −7.3 | −10.6 | −11.2 |
Perioperative RP mortality (base case = 0.0015) | |||||||||||||
None | −1.2 | −2.1 | −3.7 | −6.9 | −2.5 | −3.2 | −4.1 | −4.5 | −5.3 | −6.2 | −6.7 | −9.8 | −10.3 |
Duration of disutility due to treatment complications (base case = 5 years) | |||||||||||||
1 year | −0.6 | −1.2 | −1.9 | −4.1 | −1.2 | −1.7 | −2.3 | −2.2 | −2.5 | −2.5 | −3.0 | −4.3 | −3.9 |
One-time utility decrements (base case = age- and state-specific decrements) | |||||||||||||
50% reduction of decrements | −0.6 | −1.3 | −2.2 | −4.6 | −1.3 | −1.7 | −2.2 | −2.4 | −2.7 | −2.4 | −3.4 | −4.9 | −4.1 |
Utility for non-symptomatic health states (base case = age-specific) | |||||||||||||
Utility = 1 | −1.3 | −2.5 | −4.1 | −8.1 | −2.8 | −3.6 | −4.6 | −5.0 | −5.8 | −6.4 | −7.3 | −10.5 | −10.5 |
Predictions for men with elevated familial PCa risk | |||||||||||||
Base-case result | 1.8 | 1.7 | 0.3 | −3.9 | 3.6 | 4.6 | 5.5 | 4.7 | 7.1 | 10.6 | 5.1 | 8.2 | 13.0 |
Perioperative RP mortality (base-case = 0.0015) | |||||||||||||
None | 1.9 | 1.9 | 0.6 | −3.6 | 3.9 | 4.9 | 5.8 | 5.1 | 7.6 | 11.3 | 5.7 | 9.1 | 14.1 |
Duration of disutility due to treatment complications (base case = 5 years) | |||||||||||||
1 year | 2.6 | 3.1 | 2.6 | −0.6 | 5.4 | 6.7 | 8.0 | 7.8 | 10.9 | 15.8 | 10.0 | 15.6 | 21.9 |
One-time utility decrements (base case = age- and state-specific decrements) | |||||||||||||
50% reduction of decrements | 2.6 | 3.0 | 2.4 | −0.9 | 5.3 | 6.7 | 8.0 | 7.6 | 10.7 | 15.7 | 9.6 | 14.9 | 21.3 |
Utility for non-symptomatic health states (base case = age-specific utility) | |||||||||||||
Utility = 1 | 2.6 | 2.7 | 1.6 | −3.4 | 5.2 | 6.7 | 8.0 | 7.4 | 10.8 | 16.1 | 8.9 | 14.4 | 21.6 |
Effect of familial risk factor (base case = increase of PCa onset and progression) | |||||||||||||
Increase of PCa onset only | −2.3 | −5.8 | −13.1 | −22.0 | −5.2 | −5.5 | −5.3 | −9.5 | −8.3 | −9.0 | −17.0 | −21.6 | −19.0 |
Increase of PCa progression only | 2.2 | 2.7 | 2.4 | 0.0 | 4.8 | 6.0 | 7.1 | 7.3 | 10.1 | 14.8 | 9.5 | 14.7 | 20.6 |