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Table 2 Univariate Predictors of Mortality (p < 0.20)

From: Factors associated with mortality in HIV-infected and uninfected patients with pulmonary tuberculosis

  Univariate Analyses
Characteristics Hazard Ratio (HR) p-value1
Social and demographic variables   
Age, years 1.05 (1.03, 1.06) <0.01
Sex   
Females 1.45 (1.05, 2.00) 0.02
Karnofsky Score 0.96 (0.94, 0.97) <0.01
Karnofsky Score <70% 2.43 (1.64, 3.60) <0.01
Shillings spent on food/person/day 1 (0.999, 1) 0.09
TB related   
AFB Smear at baseline - Number of colonies   0.01
   Negative 1  
   1-9/100 fields 2.88 (0.94, 8.82)  
   10-99/100 fields 2.15 (0.86, 5.37)  
   1-10/field 2.22 (0.88, 5.62)  
   >10/field 1.20 (0.47, 3.01)  
Early Relapse2 1.60 (0.80, 3.19) 0.18
Treatment failure 1 month post-treatment initiation 0.47 (0.25, 0.88) 0.02
Has ever had TB 0.70 (0.51, 0.97) 0.03
Received TB treatment in the past 5 years 1.96 (0.96, 4.00) 0.06
Laboratory Results   
Baseline Hemoglobin, g/dL 0.73 (0.67, 0.80) <0.01
Baseline Albumin, g/L 0.83 (0.71, 0.97) 0.02
HIV- or Immune function related   
HIV infected 12.40 (7.24, 21.23) <0.01
Baseline HIV stage   
   3 1  
   4 1.94 (1.14, 3.29) 0.01
Patient progressed from stage 3 to 4 1.91 (1.28, 2.84) <0.01
Baseline CD4, per 100 cells/μL 0.57 (0.52, 0.63) <0.01
CD4 cell count, cells/μL   <0.01
   0-199 1  
   200-499 0.14 (0.09, 0.22)  
   >=500 0.04 (0.02, 0.07)  
Baseline CD3, per 100 cells/μL 0.94 (0.90, 0.98) <0.01
Baseline CD8, per 100 cells/μL 1.10 (1.06, 1.14) <0.01
CD4/CD8 Ratio 0.09 (0.05, 0.15) <0.01
RNA Viral load, per 10,000 copies/ml 1.02 (1.02, 1.03) <0.01
Log(10) viral load 2.70 (2.05, 3.54) <0.01
Log(10) viral load, quartiles   <0.01
   Q1 1  
   Q2 2.54 (1.20, 5.37)  
   Q3 3.67 (1.78, 7.56)  
   Q4 8.63 (4.38, 17.00)  
Clinical signs and symptoms   
Depression >2 weeks, ever 1.45 (0.84, 2.52) 0.19
Chronic Diarrhea 7.88 (3.22, 19.29) <0.01
Dysentery 2.22 (1.08, 4.53) 0.03
Fever 0.66 (0.47, 0.94) 0.02
Hospital admission 2.01 (0.94, 4.30) 0.07
Herpes Zoster, first episode 2.13 (0.79, 5.77) 0.14
Kaposi's Sarcoma 6.48 (1.60, 26.24) 0.01
Oral Ulcer 2.64 (1.16, 5.99) 0.02
Nausea/Vomiting 0.59 (0.28, 1.27) 0.18
Oropharyngeal candidiasis 5.16 (1.90, 13.99) <0.01
Oral candidiasis 6.90 (4.07, 11.72) <0.01
Peripheral Neuropathy 1.84 (1.04, 3.27) 0.04
Skin Rash 2.30 (1.49, 3.54) <0.01
Oral thrush 7.35 (4.33, 12.48) <0.01
Anthropometry   
Height, cm 0.97 (0.96, 0.99) <0.01
Triceps Skinfold, average of 3 measurements 1.03 (1.00, 1.07) 0.04
  1. 1 p-values obtained from Cox Regression Analyses
  2. 2 Relapse between 1-8 months post-treatment initiation if culture negative at 1 month (Early Relapse)