Table 2 Impact of age at diagnosis and late presentation with HIV on mortality
From: Older HIV-infected individuals present late and have a higher mortality: Brighton, UK cohort study
N = 1965 | Rate/1000 pyrs (95% CI) | Univariable rate ratio (95% CI) | p -value | Multivariable rate ratio (95% CI) | p -value |
|---|---|---|---|---|---|
Age at HIV diagnosis (years) | <0.0001 | <0.0001 | |||
<50 | 13.16(10.79-16.06) | 1 | 1 | ||
>50 | 35.65(24.92-50.98) | 2.70(1.80-4.08) | 2.88(1.88-4.40) | ||
CD4 count at diagnosis Cells/mm3 | <0.0001 | <0.0001 | |||
>350 | 7.59(5.16-11.14) | 1 | 1 | ||
<350 | 16.65(12.75-21.74) | 2.19(1.37-3.50) | 2.99(1.80-4.95) | ||
Unknown | 30.53(22.94-40.63) | 4.02(2.49-6.50) | 6.60(3.86-11.28) | ||
Calendar period | <0.0001 | <0.0001 | |||
1996-2001 | 42.61(31.81-57.06) | 1 | 1 | ||
2002-2005 | 12.91(9.13-18.26) | 0.30(0.19-0.48) | 0.37(0.23-0.58) | ||
2006-2010 | 10.69(8.10-14.11) | 0.25(0.17-0.38) | 0.31(0.21-0.47) | ||
Sex/HIV risk group | 0.06 | 0.43 | |||
MSM | 14.20(11.53-17.50) | 1 | 1 | ||
Female heterosexual | 12.73(7.39-21.93) | 0.90(0.50-1.61) | 0.90(0.46-1.78) | ||
Male heterosexual | 26.16(17.54-39.03) | 1.84(1.17-2.89) | 1.45(0.90-2.35) | ||
Others | 26.16(6.54-104.60) | 1.84(0.45-7.48) | 1.26(0.31-5.14) | ||
Ethnicity | 0.09 | 0.04 | |||
Caucasian | 15.21(12.56-18.41) | 1 | 1 | ||
African/Caribbean | 12.53(7.28-21.58) | 0.82(0.46-1.47) | 1.05(0.53-2.10) | ||
Others | 33.55(17.46-64.49) | 2.21(1.12-4.36) | 2.78(1.37-5.62) | ||
ART status | 0.01 | <0.0001 | |||
Not on ART | 20.81(15.81-27.38) | 1 | 1 | ||
On ART | 13.20(10.54-16.52) | 0.63(0.44-0.90) | 0.33(0.22-0.50) |