Protocol for ADDITION-PRO: a longitudinal cohort study of the cardiovascular experience of individuals at high risk for diabetes recruited from Danish primary care

Table 4 Power calculations for main outcomes in the ADDITION-PRO study

	Expected CVD events (n)	Expected incidence rate (per 1000 person years)	Power
Difference in CVD incidence between:
NGT and stable IFG/IGT	53	7.4	0.97
NGT and incident DM	100	13.8	0.99
Stable IFG/IGT and incident diabetes	132	18.3	0.59
	Detectable differences	Expected mean (SD) in reference group (NGT)	Power
Aortic stiffness (pulse wave velocity)	0.4 m/s	7.5 m/s (2.5)	0.94
Renal function (eGFR)	5 ml/min/1.73 m²	100 ml/min/1.73 m² (20)	0.98
AGE – (skin autofluorescence)	0.2 AU	2.0 AU (0.5)	0.94

AGE = advanced glycation end-products; CVD = cardiovascular disease;
eGFR = estimated glomerular filtration rate; IFG = impaired fasting glucose;
IGT = impaired glucose tolerance; NGT = normal glucose tolerance.

ISSN: 1471-2458