Volume 11 Supplement 1

## Mathematical Modelling of Influenza

# A simple model for behaviour change in epidemics

- Fred Brauer
^{1}Email author

**11(Suppl 1)**:S3

https://doi.org/10.1186/1471-2458-11-S1-S3

© Brauer; licensee BioMed Central Ltd. 2011

**Published: **25 February 2011

## Abstract

### Background

People change their behaviour during an epidemic. Infectious members of a population may reduce the number of contacts they make with other people because of the physical effects of their illness and possibly because of public health announcements asking them to do so in order to decrease the number of new infections, while susceptible members of the population may reduce the number of contacts they make in order to try to avoid becoming infected.

### Methods

We consider a simple epidemic model in which susceptible and infectious members respond to a disease outbreak by reducing contacts by different fractions and analyze the effect of such contact reductions on the size of the epidemic. We assume constant fractional reductions, without attempting to consider the way in which susceptible members might respond to information about the epidemic.

### Results

We are able to derive upper and lower bounds for the final size of an epidemic, both for simple and staged progression models.

### Conclusions

The responses of uninfected and infected individuals in a disease outbreak are different, and this difference affects estimates of epidemic size.

## Keywords

## Introduction

During the course of an epidemic, there are changes in behaviour which have an effect on the transmission of infection. Individuals who are infected may make fewer contacts with others because the debilitating effects of their illness or because of advice by public health organizations to stay home in order to avoid infecting others. Individuals who have not been infected may take hygienic measures to reduce the risk of being infected and may take other steps such as avoidance of large public gatherings. There is evidence that such measures had substantial effects during the 1918 influenza pandemic [1].

The question of what factors influence people to change their behaviour is a difficult one, probably more in the areas of psychology and sociology than epidemiology and public health. In this study, we avoid this question, and assume only reduction of contacts sufficient to transmit infection by members of the population. Since the factors affecting such behaviour changes are different for those who are infected and those who wish to avoid becoming infected, it is necessary to assume different fractional reductions in these two groups. This implies that, even in a model in which mixing is assumed homogeneous without behavioural change, it is necessary to recognize that the mixing becomes heterogeneous, and this may affect the behaviour of the model.

In this note, our purpose is to estimate the effect that given reductions in contacts have on the final size of an epidemic, without trying to model the factors that might cause such reductions. It would be more realistic to assume that the rate or amount of behavioural change, at least for uninfected members of the population, is dependent on some information about the extent of the epidemic, perhaps the number of infectious people or the total number of reported disease deaths. Study of such questions is one of the most important gaps in scientific knowledge of the spread of communicable diseases. One contribution in the direction of studying this area is [4]

## A simple *SIR*epidemic model

*βN*contacts in unit time, that there is an exponential distribution of infected periods with mean length 1/

*α*, and that there are no disease deaths (so that the total population size

*N*remains constant) [5]. We assume that initially the population consists of

*S*

_{0}susceptible members and a (presumably small) number

*I*

_{0}of infectious members, with

*S*

_{0}+

*I*

_{0}=

*N*. For the model (1) it is known that the basic reproduction number is

*S*

_{ ∞ }and the number of infectious members decreases to zero as

*t → ∞*, and that the attack rate, the extent of the epidemic which is defined as

This was originally derived in [5], although the basic reproduction number was not given explicitly. More recent derivations may be found in [2, 6].

Since (1) is a two-dimensional autonomous system of differential equations, the natural approach would be to find equilibria and linearize about each equilibrium to determine its stability. However, since every point with *I* = 0 is an equilibrium, the system (1) has a line of equilibria and this approach is not applicable (the linearization matrix at each equilibrium has a zero eigenvalue). It is possible to analyze the system in the phase plane (the (*S*, *I*) plane) obtaining a phase portrait and also the final size relation. Although this derivation of the final size relation is simple and has a useful geometric interpretation, it does not generalize readily to more complicated compartmental models. For this reason, we give also an analytic argument which does generalize.

Because *S* is a decreasing non-negative function, it has a limit *S*_{
∞
} ≥ 0 as *t* → ∞*.* The sum of the two equations of (1) is

(*S + I*)′ *=* –*αI.*

*S + I*is a non-negative smooth decreasing funtion and therefore tends to a limit as

*t → ∞*. Also, it is not difficult to prove that the derivative of a smooth decreasing function must tend to zero, and this shows that

Thus *S + I* has limit *S*_{
∞
}.

Division of the first equation of (1) by *S* and integration from 0 to *∞* gives the final size relation (2). We now modify the model (1) by assuming that susceptible members decrease their rate of contact by a fraction *p*, 0 *≤ p ≤* 1 and that infectious members decrease their rate of contact by a fraction *q*, 0 *≤ q ≤* 1. As different subgroups of the population now have different activity levels, we must specify the mixing between groups. Since the population is assumed to mix homogeneously in the absence of disease, we assume proportionate mixing. Thus we assume that the number of contacts in unit time made by susceptible members, infectious members, and removed members are, respectively,

*pβN*, *qβN*, *βN*,

It is convenient to define

*T = pS + qI + R*,

*S + I*)

*′ =*–

*αI*it follows that

*I →*0 as

*t → ∞*, and from integration of this equation it follows that

so that

*R*_{0} = *qR*^{
∗
} *≤ R*^{
∗
}.

It is clear that

*R*_{1}*≤ R*_{0}, *R*_{1}*≤ R*^{
∗
}, *R*_{0}*≤ R*_{2}*≤ R*^{
∗
}*,*.

In addition,

*R*_{0}*< R*^{
∗
} (*q <* 1), *R*_{1}*< R*^{
∗
} (*pq <* 1), *R*_{1}*< R*_{0} (*p <* 1)

*R*_{2}*< R*^{
∗
} (*p <* 1, *q <* 1), *R*_{2} = *R*_{0} (*p ≤ q*)*.*

## The final size equation

*S*

_{ ∞ }as a function

*S*

_{ ∞ }(

*R*) of

*R*. It is easy to show [2] that the final size relation (9) has a unique solution

*S*

_{ ∞ }with

Using implicit differentiation of (9) and this estimate, it is easy to see that the function *S*_{
∞
}(*R*) is strictly decreasing. The final size inequalities (8) imply that for the model (3) the final size *S*_{
∞
} satisfies the inequalities

*S*_{
∞
}(*R*_{2}) *< S*_{
∞
} *< S*_{
∞
}(*R*_{1})*.*

The behavioural response in the model (3) decreases the final susceptible population size from *S*_{
∞
}(*R*^{
∗
}) to *S*_{
∞
}(*R*_{2}) or less. If one ignores the heterogeneity in the model, one might assume that the final susceptible population size is *S*_{
∞
}(*R*_{0}). If *p > q*, so that *R*_{2}*> R*_{0}, it is possible that the final susceptible population size could be smaller than this. However, simulations suggest that the final susceptible population size is usually larger than *S*_{
∞
}(*R*_{0}).

For example we simulate the model (3) with parameters

*βN* = 0*.*45, *α* = 0*.*25, *p* = 0*.*9, *q* = 0*.*8,

so that

*R*_{0} = 1*.*44, *R*^{
∗
} = 1*.*8, *R*_{1} = 1*.*30, *R*_{2} = 1*.*62*.*

*S*

_{ ∞ }= 483

*.*3. The reproduction number corresponding to this value of

*S*

_{ ∞ }, which we may call the effective reproduction number, denoted by

*R*

_{ E }, is 1

*.*405. Further simulations suggest that the effective reproduction number is likely to be close to and somewhat smaller than

*R*

_{0}. In fact, since

*R*

_{2}=

*R*

_{0}if

*p ≤ q*, (7) may be replaced by

Even if *p >* *q* the upper bound in (10) may be valid. Simulations suggest that the upper bound is valid except possibly when *p* is very close to 1, *q* is very close to zero, and *R*_{0} is well below 1. It is possible to find examples for which *R*_{
E
} *> R*_{0}, such as *p* = 0*.*9, *q* = 0*.*2, which gives

*R*_{0} = 0*.*36, *R*_{1} = 0*.*324, *R*_{2} = 1*.*62, *R*_{
E
} = 0*.*375*.*

This indicates that behavioural response of the type assumed here usually reduces the size of the epidemic a little more than might be expected by a naive approach.

## Staged progression epidemic models

*SI*

_{1}

*I*

_{2}⋯

*I*

_{ n }model in which the relative infectivity in stage

*j*is

*ε*

_{ j }, and the rate of transfer to the next stage is

*α*

_{ j }. This leads to the model

*j*reduce their contacts by a factor

*q*

_{ j }, and that the mixing between groups is proportionate. Then the rate of contacts in unit time by susceptibles is

*pβN*, and the fraction of these contacts that are with infectious members in stage

*j*is

*q*

_{ j }

*/T*, where

To obtain an upper bound, we use the inequality

*T ≥* min(*p*, *q*_{1}, *q*_{2}, ⋯ , *q*_{
n
})*N.*

We may summarize these calculations by saying that the bounds obtained for the simple *SIR* model extend to the staged progression model (12). There is no difficulty in extending to staged progression models with arbitrarily distributed length of stay in each stage. The mean time in stage *j* replaces 1*/α*_{
j
} in each estimate. We have not carried out the calculations here because of the technical complications in writing the model equations, but these may be found in [3].

## Conclusions

Behavioural changes are an essential aspect of the course of an epidemic. The changes in behaviour by infectious members of a population have different causes than the changes in behaviour by uninfected members, and a model incorporating behavioural changes should reflect this. One implication is that a model incorporating behavioural changes must include heterogeneous mixing. One consequence of this is that the final size of an epidemic can not be determined exactly from a final size relation but can only be approximated. There is an effective reproduction number which is less than the basic reproduction number in many cases but not necessarily always.

Epidemic models with age structure or other heterogeneities in mixing can also be extended to incorporate behavioural changes. This would result in models with complicated mixing behaviour that would be difficult to analyze. There would be a system of final size equations which could not be solved exactly, but would still yield final size estimates. An important question that has not yet been attacked is the formulation of models that include behavioural responses, especially by uninfected members of the population, that depend on the state and history of the epidemic.

## Declarations

### Acknowledgements

This article has been published as part of *BMC Public Health* Volume 11 Supplement 1, 2011: Mathematical Modelling of Influenza. The full contents of the supplement are available online at http://0-www.biomedcentral.com.brum.beds.ac.uk/1471-2458/11?issue=S1.

## Authors’ Affiliations

## References

- Bootsma MCJ, Ferguson NM: The effect of public health measures on the 1918 influenza pandemic in U.S. cities. Proc Natl Acad Sci U S A. 2007, 104 (18): 7588-7593. 10.1073/pnas.0611071104.PubMed CentralView ArticlePubMedGoogle Scholar
- Brauer F: Age-of-infection and the final size relation. Math Biosci Eng. 2008, 5 (4): 681-690. 10.3934/mbe.2008.5.681.View ArticlePubMedGoogle Scholar
- Brauer F, Castillo-Chavez C, Feng Z: Discrete epidemic models. Math Biosci Eng. 2010, 7 (1): 1-15. 10.3934/mbe.2010.7.1.View ArticlePubMedGoogle Scholar
- del Valle S, Hethcote HW, Hyman JM, Castillo-Chavez C: Effects of behavioral changes in a smallpox attack model. Math Biosci. 2005, 195 (2): 228-251. 10.1016/j.mbs.2005.03.006.View ArticlePubMedGoogle Scholar
- Kermack WO, McKendrick AG: A contribution to the mathematical theory of epidemics. Proc. Royal Soc. London. 1927, 115: 700-721. 10.1098/rspa.1927.0118.View ArticleGoogle Scholar
- Ma J, Earn DJD: Generality of the final size formula for an epidemic of a newly invading infectious disease. Bull. Math. Biol. 2006, 68: 679-702. 10.1007/s11538-005-9047-7.View ArticlePubMedGoogle Scholar
- Van den Driessche P, Watmough J: Reproduction numbers and subthreshold endemic equilibria for compartmental models of disease transmission. Math Biosci. 2000, 180: 29-48. 10.1016/S0025-5564(02)00108-6.View ArticleGoogle Scholar

## Copyright

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.