- Research article
- Open Access
- Open Peer Review
Do patients with recurrent episodes of campylobacteriosis differ from those with a single disease event?
© Arsenault et al; licensee BioMed Central Ltd. 2011
- Received: 20 August 2010
- Accepted: 12 January 2011
- Published: 12 January 2011
Although Campylobacter is the leading cause of reported bacterial gastro-enteritis in industrialized countries, little is known on its recurrence. The objective of this study is to describe the risk and the patient characteristics of recurrent episodes of human campylobacteriosis reported in Quebec.
Laboratory-confirmed cases of campylobacteriosis reported in the province of Quebec, Canada, through ongoing surveillance between 1996 and 2006 were analyzed. The risk of having a recurrent episode of campylobacteriosis was described using life table estimates. Logistic regression was used to assess if gender, age and patient residential location were associated with an increased risk of recurrence.
Compared to the baseline risk, the risk for a recurrent disease event was higher for a period of four years and followed a decreasing trend. This increased risk of a recurrent event was similar across gender, but higher for people from rural areas and lower for children under four years of age.
These results may suggest the absence of durable immunity or clinical resilience following a first episode of campylobacteriosis and periodical re-exposure, at least among cases reported through the surveillance system.
- Recurrent Episode
- Previous Episode
- Proxy Date
- Surveillance Database
In Canada, infection by Campylobacter spp. is the leading cause of bacterial gastro-enteritis, with an average of 39 cases per 100,000 people reported annually over the last decade . However, given the mild clinical expression of most Campylobacter infections, this reflects an underestimation of the true burden in the population, as only a fraction of people affected consult their physician and have stool samples submitted for culture .
In Canada as in many other countries, human campylobacteriosis is a reportable disease. Regional public health authorities are notified of confirmed cases and selected information is then gathered into surveillance databases. These databases can then be used in epidemiological investigations as sources of information for evaluating individual or environmental risk factors [3, 4]. It was recently proposed that acquired immunity to the infection could bias results from risk factor analysis by reducing the risk of developing the disease in areas of high exposure .
Following an infection with Campylobacter, most people develop a humoral immune response. Circulating antibodies are detectable six to seven days after the onset of the disease . The antibody peak occurs within 7 days to 4 weeks, depending on the specific serum immunoglobulin, and then declines over several months . Although the development of antibodies following a Campylobacter infection is well recognized, their protective role is poorly understood, especially in populations living in developed countries .
One of the potential avenues of exploring the possible protective effect of immunity is through studying recurrence. Immunity following a first episode of campylobacteriosis would be associated with a reduced risk for subsequent events, which might also vary in time and according to patient characteristics. Characterization of the risk of recurrent episodes may also bring valuable insight to the question of whether or not to include patients with multiple reports of the disease in risk factor analyses. The objective of this study is therefore to describe the risk of having a recurrent episode of campylobacteriosis in relation to patient characteristics.
This study was designed as a retrospective analysis of human campylobacteriosis cases reported through ongoing surveillance in the province of Quebec, Canada, between January 1, 1996 and December 31, 2006. Cases from non-organized territories, incompletely enumerated First Nations reserves, and areas located north of the 55th parallel were excluded.
Following approval of the project by the research ethics board of the Montreal Health and Social Services Agency, all laboratory-confirmed cases of campylobacteriosis were retrieved from each the health region's reportable disease database. Case information extracted includes a de-identified record number, age, gender, Campylobacter species isolated, various dates related to onset and report, place of residence, and outcome. Cases were geocoded at the municipality level (using 2006 boundaries). Patients were then classified as living in an urban region if their municipality of residence was entirely within an urban area, as rural if entirely outside, or as semi-urban if otherwise. An urban area was defined according to Statistics Canada as an area with a population of at least 1,000 people and no fewer than 400 persons per km2 (Statistics Canada, 2003).
Population census data by age, gender, and census subdivisions (CSD) were obtained from Statistics Canada for the census years of 1996, 2001, and 2006. A weighted average annual population for each CSD was calculated over the three census years using 0.25, 0.5, and 0.25 weights, respectively. A weighted average annual population by urbanicity was also calculated using a similar method.
Date of onset
For each reported case, the date of onset was retrieved directly from the database when available. If this date was missing, an estimation was performed using a "proxy date" based on the first of the following dates with a non-missing value: date of sample collection, date of physician notification, date of laboratory notification, date of reception of physician report by authorities, and/or date of reception of laboratory report by authorities. When date of onset had to be estimated, the median time period (in days, by health region) between the onset and proxy date was subtracted from a case's specific proxy date and used as the estimated date of onset.
Reported cases of recurrent episodes of campylobacteriosis were identified using unique de-identified record numbers. Episodes of campylobacteriosis occurring within 90 days of the date of onset of a prior episode were excluded sincethese cases were diagnosed within the recognized reported interval for duration of bacterial excretion [7, 8] and in consideration of the 90 day cut-off time used by health officers for multiple entry detection and removal during the validation process of reportable disease databases .
Descriptive statistics were used to investigate the frequency distribution of patients according to the number of episodes of campylobacteriosis reported, and the distribution of the time lag between two consecutive episodes. For patients with multiple episodes, the association between Campylobacter species (jejuni, coli, etc.) isolated in first and second episodes was tested using the exact McNemar test and performed in SAS 9.2.
The baseline incidence of campylobacteriosis was estimated by taking all first episode cases and dividing them by the average population. This estimation was performed for all combined cases and then stratified by gender, age, and urbanicity. Age of patients was classified as 0-4 yrs, 5-14 yrs, 15-44 yrs, 45-64 yrs, and >65 yrs. A confidence interval (95%) for the average baseline incidence of campylobacteriosis was estimated under the normal distribution assumption, and results were then converted to an annual rate per 100,000 people.
The annual risk of having a recurrent episode of campylobacteriosis was estimated among reported cases using a survival analysis. These cases were then stratified by gender, age, and urbanicity and a survival analysis was performed again on each category. Survival function was inferred from life-table estimates in SAS 9.1. Time of entry of each patient into the analysis was set as the date of onset of the first episode plus 90 days. However, for the analysis by age group, time of entry was set as the day at which the patient reached the lower bound of the age group studied plus 90 days. For the analysis by urbanicity, the category was determined by the type of region noted upon first episode, since information on changes in residency regions was not complete. Time-to-event was estimated as the interval of time between the time of entry and a second episode. Right censoring was used for patients with no other reported episodes, with time-to-censoring calculated as the time between entry in the analysis and the last day of the study. For the analysis by age group, right censoring was also used when the age of the patient reached the upper bound of the age group studied. The risk of campylobacteriosis with a 95% confidence interval was estimated at the mid-point of 6-month intervals, and the risk was converted to an annual rate per 100,000 people. However, for the analyses by gender, age, or urbanicity, the studied time period was restricted to the 5 years following the first episode, with the risk calculated at the mid-point of this 5-year interval. Due to the low number of cases in these stratum-specific analyses, the use of 6-month intervals would have led to very large confidence intervals.
Incidence rates according to patient characteristics
First episode (11 years of follow-up)
Second episode (5 years of follow-up)
Ratio in ratesc
Average population at risk per year
Episode per year per 100,000 (95% C.L)
Effective population at riskb
Episode per year per 100,000 (95% C.L)
40.7 (40.0, 41.3)
262.8 (222.5, 303.2)
32.4 (31.9, 33.0)
230.9 (189.8, 272.1)
Age category (yrs) d
56.1 (53.9, 58.4)
252.9 (129.0, 376.8)
28.3 (27.3, 29.4)
183.6 (106.9, 260.3)
45.1 (44.3, 45.8)
430.7 (367.1, 494.3)
25.6 (24.9, 26.3)
247.8 (171.0, 324.6)
28.8 (27.8, 29.9)
269.0 (165.6, 372.4)
42.8 (41.5, 44.1)
385.6 (289.6, 481.6)
42.0 (41.3, 42.6)
267.8 (227.6, 308.1)
27.3 (26.7, 27.9)
148.6 (107.8, 189.4)
36.5 (36.0, 36.9)
248.0 (219.2, 276.9)
A total of 29,407 episodes of laboratory-confirmed cases of campylobacteriosis were recorded in the surveillance database between 1996 and 2006, inclusively. From these, 158 were excluded because a previous episode was recorded within 90 days of the date of onset. The remaining 29,249 episodes were linked to 28,905 patients for an average of 1.01 episodes per patient. Mortality related to campylobacteriosis was recorded for 6 patients.
Campylobacter species isolated
Second episode (within a 5-year interval)
jejuni and coli
jejuni and coli
jejuni and coli
jejuni and coli
Description of the risk of recurrent episode
According to the logistic regression model for gender, no statistically significant interaction was observed (P = 0.42, LRT) between gender and a previous episode of campylobacteriosis within the ensuing 5 years, suggesting that a previous episode increased the risk of campylobacteriosis by the same magnitude for both genders. This interaction was thus removed from the model. The estimates for gender (OR = 1.3 for male versus female) and a previous episode (OR: 6.8) were statistically significant (P < 0.001, LRT). For the logistic regression model including age, the interaction between age and a previous episode was statistically significant (P = 0.03, LRT). According to post-hoc pairwise comparisons, the increase in the risk of campylobacteriosis following a first episode was lower in the 0-4 age group compared to the other age groups (OR = 2.1 to 2.2, P > 0.02). Finally, according to the logistic regression model including urbanicity, a statistically significant interaction (P = 0.02, LRT) was observed between the type of region and a previous episode. Post-hoc pairwise comparisons revealed that the impact of having had a previous episode of campylobacteriosis on the risk of a subsequent episode was greater in rural areas compared to semi-urban (OR = 1.4, P = 0.02) or urban (OR = 1.7, P = 0.008) areas.
According to our results, the risk of a recurrent episode of campylobacteriosis was 248 for every 100,000 patients per year on average for the first 5 years following a first episode. This means that approximately 1.2% of patients with a reported episode of campylobacteriosis suffer from another episode within the next five years. Although this percentage might seem low, it represents a much higher risk than the one observed in the general population.
The relatively high rate of recurrence in campylobacteriosis cases may suggest that people in Quebec, like in other regions of industrialized countries, might be exposed to Campylobacter at lower levels than needed to develop an effective immunity. This would be in agreement with other studies which conclude that the development of immunity against Campylobacter is most likely limited to developing countries, where individuals are most likely exposed to a highly contaminated environment, characterized for example by a poor quality water supply or by the presence of poultry in the house [5, 8, 10, 11]. Partial immunity in developing countries is supported by children excreting the bacteria for shorter duration and by disproportionately higher risk in travellers . In industrialized countries, the exposure to Campylobacter is considered much lower, which translates into lower incidence rates of campylobacteriosis in children and a lower percentage of carriers [11, 13, 14]. One of the few documented instances of acquired immunity to Campylobacter infection in industrialized countries is with people professionally exposed, such as poultry abattoir workers [15, 16]. This fraction of the population, although likely present among the cases reported in the province of Quebec, is probably too small to have had an impact in our study. Another study conducted in Scotland found some evidence of age-acquired immunity to common serotypes , whereas immunity to common genotypes was proposed as an explanation for reduction in incidence of campylobacteriosis in some countries .
Our data did not show evidence of the development of Campylobacter species-specific immunity, since people with recurrent episodes were as likely to have been infected twice by the same Campylobacter species. However, Campylobacter strains for the same species are reported to present a high genetic diversity . Thus, immunity is expected to develop for strains sharing similar antigenic properties, which could not be evaluated in this study. This analysis could have been biased by the exclusion of some cases involving other or multiple species; however, this exclusion amounted to only 1% of cases. It should be remembered that reported cases represent only a small fraction of all cases occurring in the population. It would be interesting to evaluate if patients with more severe clinical presentations are similar in terms of immune response and risk of recurrence when compared to milder cases.
In addition to the lack of evidence of an acquired immunity, a prior episode seems to increase the risk of reporting a second episode of campylobacteriosis. Campylobacteriosis might cause long-term perturbations of intestinal physiology leading to an increased susceptibility to enteric diseases in general . Long-term patho-physiological consequences of Campylobacter infections are also supported by a Danish study that noted an increased mortality following a reported episode of campylobacteriosis for the year following the episode, even after adjustment for comorbidity . Unfortunately, no information was available on the significance of relapses or recurrent episodes in the explanation of this excess risk.
It is also possible that the higher risk is driven by some sub-groups of the population with diseases that predispose them to a high risk of recurrence. In the literature, there are reported cases of patients with hypogammaglobulinemia who experienced recurrent episodes of campylobacteriosis ; however, recurrent episodes were closer in time than what we observed and a predisposing disease such as this is rare. Other diseases were reported as risk factors for campylobacteriosis, including AIDS, chronic intestinal diseases, diabetes, liver disease and metastatic cancers [21, 23–25]. The use of antacid or antibiotics is also associated with a higher risk of campylobacteriosis [26–28]. This can also be the case for people using corticosteroids. These drugs are commonly prescribed for a wide variety of diseases such as asthma, rheumatism, allergies, and renal disorders, and their chronic use is associated with an increased risk of infectious diseases .
Another sub-group at possible higher risk would be travelers; according to surveillance data collected in the region of Waterloo, 19% of reported cases of campylobacteriosis were associated with international traveling . Travel-associated cases are likely overestimated in surveillance databases, because people traveling abroad in the days preceding a diarrheal episode are more likely to seek medical advice, even after adjustment for disease severity . It is possible that people do develop immunity against Campylobacter, but that such immunity is not effective when exposed to uncommon strains or to a highly contaminated environment when traveling in developing countries. In the Quebec surveillance database on reportable diseases, data on the occupation of the patient and whether cases are related to out of province travel were missing for 85% and 96% of patients respectively, making any analysis unfeasible. From another perspective, people with a previous diagnosis of campylobacteriosis might be more inclined to consult their physician when they experience another episode of acute gastroenteritis. In fact, the overall risk of campylobacteriosis in Canada has been estimated to be approximately 1.5% per year , which is very close to our 1.2% estimate.
The higher rate of recurrence for those with a previous infection of Campylobacter is suggestive of long-term or recurrent rather than punctual exposure, for example via an occupational exposure to animals, a source of drinking water or food habits [32–34]. This could be of particular importance for people living in rural areas where infection through drinking raw milk or being in direct contact with excreting farm animals is more likely [32, 35]. This could be also true for young children who have closer contact with their environment due to specific behaviors. A long-term or recurrent exposure from a specific source is also suggested when Campylobacter coli is frequently isolated (i.e. 36%) in successive episodes but not commonly isolated in the general population. Campylobacter coli is known to be strongly associated with swine and certain environmental sources . These speculations are supported by our results which show that the risk of campylobacteriosis following a first reported episode is higher in infants and people from rural regions.
Some assumptions underpinning this study must be mentioned. First, a proxy estimation was used for the date of campylobacteriosis onset, which is a potential source of error. However, we do not have reason to believe that this method biases the results. Moreover, the possibility that chronic cases were identified as recurrent cases is low. In fact, cases occurring less than 3 months from first episodes were excluded, and campylobacteriosis typically lasts less than 7 days [37, 38] and bacterial excretion following the resolution of clinical signs persists for only two to nine weeks [7, 39]. It was assumed that all people having had a reported episode of campylobacteriosis remained at risk of having another one up to the end of the study. However, information on patient mortality occurring after the episode was not available, and episodes reported in two different health regions for a single patient were not necessarily identified by a single identifier. Despite this fact, any death or move would have led to a reduction in the number of reported episodes, and ultimately to the same conclusions. Based on our observations and other reports, the fatality rate associated with reported campylobacteriosis episodes in Canada is typically less than 1% . Likewise, the impossibility of linking cases occurring in a single patient but reported in different health regions would also lead to an underestimation of the risk of recurrent episodes, because this would lead to underestimating the number of cases of recurrent episodes. Finally, a misclassification bias could be present in our study, since patients with only one reported episode could have had another episode prior to our study time period. Likewise, not all patients stayed in the same region type for the entire study period; city dwellers can also move to cottages on a regular basis for short or long periods of time, yet remain classified as urban for statistical purposes. These misclassifications, if present, would have likely produced more conservative results with a reduction of the risk difference observed.
We used a logistic model to study the risk of recurrent episodes according to patient characteristics. This model did not take into account the correlation between individuals included twice in the analysis. Attempts were made to fit models using multi-level or generalized estimating equation methods but no convergence was obtained. The restriction of the analysis to patients having had a first episode would have led to misleading results due to the inability to adjust forr stratum-specific baseline risks. Development and validation of statistical models for studying recurrent episodes in this setting could be an issue to consider .
Data arising from surveillance systems, although imperfect, represent an invaluable source of information for studying the epidemiology of infectious diseases such as campylobacteriosis. However, given the experience of this study, such data would be further enhanced by capturing information related to domestic travel, underlying medical conditions, antacid or antibiotic use, and occupational information.
When compared to a baseline risk, the risk for a recurrent episode of campylobacteriosis was increased for four years and followed a decreasing trend. This increased risk of a recurrent event was similar across gender, but higher for people from rural areas and lower for children under four years old. These results may suggest the absence of durable immunity or clinical resilience following a first episode of campylobacteriosis and periodic re-exposure, at least among cases reported through the surveillance system. A follow-up study on recurrent cases might be useful for understanding specific patient characteristics involved in this higher risk of recurrence. These results also suggest that recurrent cases of campylobacteriosis should be excluded from risk factor analyses, or that the correlation between episodes occurring in the same individual should be taken into account. Lastly, this data revealed some level of specificity in the epidemiology of campylobacteriosis for population sub-groups such as children and people living in rural areas. Patients experiencing campylobacteriosis would benefit from being informed about potential sources of contamination and adequate preventive measures.
We would like to acknowledge the 16 health regions in Quebec for sharing their surveillance data. This project was financially supported by the Canadian Institutes of Health Research and by the Faculty of Veterinary Medicine of the Université de Montréal through research grants to J. Arsenault.
- Notifiable Diseases On-Line. [http://dsol-smed.phac-aspc.gc.ca/dsol-smed/ndis/index_e.html]
- Thomas MK, Majowicz SE, Sockett PN, Fazil A, Pollari F, Doré K, Flint JA, Edge VL: Estimated numbers of community cases of illness due to Salmonella, Campylobacter and verotoxigenic Escherichia coli: Pathogen-specific community rates. Can J Infect Dis Med Microbiol. 2006, 17: 229-234.PubMedPubMed CentralGoogle Scholar
- Gillespie IA, O'Brien SJ, Frost JA, Adak GK, Horby P, Swan AV, Painter MJ, Neal KR: A case-case comparison of Campylobacter coli and Campylobacter jejuni infection: a tool for generating hypotheses. Emerg Infect Dis. 2002, 8: 937-942.View ArticlePubMedPubMed CentralGoogle Scholar
- Green CG, Krause D, Wylie J: Spatial analysis of Campylobacter infection in the Canadian province of Manitoba. Int J Health Geogr. 2006, 5: 2-10.1186/1476-072X-5-2.View ArticlePubMedPubMed CentralGoogle Scholar
- Havelaar AH, van Pelt W, Ang CW, Wagenaar JA, van Putten JP, Gross U, Newell DG: Immunity to Campylobacter: its role in risk assessment and epidemiology. Crit Rev Microbiol. 2009, 35: 1-22. 10.1080/10408410802636017.View ArticlePubMedGoogle Scholar
- Janssen R, Krogfelt KA, Cawthraw SA, van Pelt W, Wagenaar JA, Owen RJ: Host-pathogen interactions in Campylobacter infections: the host perspective. Clin Microbiol Rev. 2008, 21: 505-518. 10.1128/CMR.00055-07.View ArticlePubMedPubMed CentralGoogle Scholar
- Wright EP: Duration of excretion period of Campylobacter jejuni in human subjects. Campylobacter: Epidemiology, pathogenesis and Biochemistry. Edited by: Newell DG. 1981, Lancaster, England: MTP Press Limited, 294-298.Google Scholar
- Rao MR, Naficy AB, Savarino SJ, Abu-Elyazeed R, Wierzba TF, Peruski LF, Abdel-Messih I, Frenck R, Clemens JD: Pathogenicity and convalescent excretion of Campylobacter in rural Egyptian children. Am J Epidemiol. 2001, 154: 166-173. 10.1093/aje/154.2.166.View ArticlePubMedGoogle Scholar
- Ministère de la Santé et des Services sociaux du Québec: Surveillance des maladies à déclaration obligatoire au Québec. 2002, Québec: Direction de la santé publique, Bureau de surveillance et de vigie sanitaireGoogle Scholar
- Richardson NJ, Koornhof HJ, Bokkenheuser VD, Mayet Z, Rosen EU: Age related susceptibility to Campylobacter jejuni infection in a high prevalence population. Arch Dis Child. 1983, 58: 616-619. 10.1136/adc.58.8.616.View ArticlePubMedPubMed CentralGoogle Scholar
- Coker AO, Isokpehi RD, Thomas BN, Amisu KO, Obi CL: Human campylobacteriosis in developing countries. Emerg Infect Dis. 2002, 8: 237-244. 10.3201/eid0803.010233.View ArticlePubMedPubMed CentralGoogle Scholar
- Oberhelman RA, Taylor DN: Campylobacter infections in developing countries. Campylobacter. Edited by: Nachamkin I, Blaser MJ. 2000, Washington, D.C.: ASM Press, 139-153. 2Google Scholar
- Baffone W, Bruscolini F, Pianetti A, Biffi MR, Brandi G, Salvaggio L, Albano V: Diffusion of thermophilic Campylobacter in the Pesaro-Urbino area (Italy) from 1985 to 1992. Eur J Epidemiol. 1995, 11: 83-86. 10.1007/BF01719950.View ArticlePubMedGoogle Scholar
- Hellard ME, Sinclair MI, Hogg GG, Fairley CK: Prevalence of enteric pathogens among community based asymptomatic individuals. J Gastroenterol Hepatol. 2000, 15: 290-293. 10.1046/j.1440-1746.2000.02089.x.View ArticlePubMedGoogle Scholar
- Cawthraw SA, Lind L, Kaijser B, Newell DG: Antibodies, directed towards Campylobacter jejuni antigens, in sera from poultry abattoir workers. Clin Exp Immunol. 2000, 122: 55-60. 10.1046/j.1365-2249.2000.01349.x.View ArticlePubMedPubMed CentralGoogle Scholar
- Forbes KJ, Gormley FJ, Dallas JF, Labovitiadi O, MacRae M, Owen RJ, Richardson J, Strachan NJ, Cowden JM, Ogden ID, McGuigan CC: Campylobacter immunity and coinfection following a large outbreak in a farming community. J Clin Microbiol. 2009, 47: 111-116. 10.1128/JCM.01731-08.View ArticlePubMedGoogle Scholar
- Miller G, Dunn GM, Reid TM, Ogden ID, Strachan NJ: Does age acquired immunity confer selective protection to common serotypes of Campylobacter jejuni?. BMC Infect Dis. 2005, 5: 66-10.1186/1471-2334-5-66.View ArticlePubMedPubMed CentralGoogle Scholar
- Gormley FJ, Macrae M, Forbes KJ, Ogden ID, Dallas JF, Strachan NJ: Has retail chicken played a role in the decline of human campylobacteriosis?. Appl Environ Microbiol. 2008, 74: 383-390. 10.1128/AEM.01455-07.View ArticlePubMedGoogle Scholar
- Dingle KE, Colles FM, Wareing DR, Ure R, Fox AJ, Bolton FE, Bootsma HJ, Willems RJ, Urwin R, Maiden MC: Multilocus sequence typing system for Campylobacter jejuni. J Clin Microbiol. 2001, 39: 14-23. 10.1128/JCM.39.1.14-23.2001.View ArticlePubMedPubMed CentralGoogle Scholar
- Gradel KO, Norgaard M, Dethlefsen C, Schonheyder HC, Kristensen B, Ejlertsen T, Nielsen H: Increased risk of zoonotic Salmonella and Campylobacter gastroenteritis in patients with haematological malignancies: a population-based study. Ann Hematol. 2009, 88: 761-767. 10.1007/s00277-008-0662-x.View ArticlePubMedGoogle Scholar
- Helms M, Vastrup P, Gerner-Smidt P, Molbak K: Short and long term mortality associated with foodborne bacterial gastrointestinal infections: registry based study. BMJ. 2003, 326: 357-10.1136/bmj.326.7385.357.View ArticlePubMedPubMed CentralGoogle Scholar
- LeBar WD, Menard RR, Check FE: Hypogammaglobulinemia and recurrent Campylobacter jejuni infection. J Infect Dis. 1985, 152: 1099-1100.View ArticlePubMedGoogle Scholar
- Neal KR, Slack RC: Diabetes mellitus, anti-secretory drugs and other risk factors for Campylobacter gastro-enteritis in adults: a case-control study. Epidemiol Infect. 1997, 119: 307-311. 10.1017/S0950268897008224.View ArticlePubMedPubMed CentralGoogle Scholar
- Danis K, Di Renzi M, O'Neill W, Smyth B, McKeown P, Foley B, Tohani V, Devine M: Risk factors for sporadic Campylobacter infection: an all-Ireland case-control study. Euro Surveill. 2009, 14:Google Scholar
- Stafford RJ, Schluter PJ, Wilson AJ, Kirk MD, Hall G, Unicomb L: Population-attributable risk estimates for risk factors associated with Campylobacter infection, australia. Emerg Infect Dis. 2008, 14: 895-901. 10.3201/eid1406.071008.View ArticlePubMedPubMed CentralGoogle Scholar
- Doorduyn Y, Van Den Brandhof WE, VAN Duynhoven YT, Breukink BJ, Wagenaar JA, VANP W: Risk factors for indigenous Campylobacter jejuni and Campylobacter coli infections in The Netherlands: a case-control study. Epidemiol Infect. 2010, 1-14.Google Scholar
- Neal KR, Scott HM, Slack RC, Logan RF: Omeprazole as a risk factor for Campylobacter gastroenteritis: case-control study. BMJ. 1996, 312: 414-415.View ArticlePubMedPubMed CentralGoogle Scholar
- Effler P, Ieong MC, Kimura A, Nakata M, Burr R, Cremer E, Slutsker L: Sporadic Campylobacter jejuni infections in Hawaii: associations with prior antibiotic use and commercially prepared chicken. J Infect Dis. 2001, 183: 1152-1155. 10.1086/319292.View ArticlePubMedGoogle Scholar
- Klein NC, Go CH, Cunha BA: Infections associated with steroid use. Infect Dis Clin North Am. 2001, 15: 423-432. 10.1016/S0891-5520(05)70154-9. viiiView ArticlePubMedGoogle Scholar
- Public Health Agency of Canada: C-EnterNet 2006 Annual Report/National Integrated Enteric Pathogen Surveillance Program. 2007, Public Health Agency of CanadaGoogle Scholar
- Tam CC, Rodrigues LC, O'Brien SJ: The study of infectious intestinal disease in England: what risk factors for presentation to general practice tell us about potential for selection bias in case-control studies of reported cases of diarrhoea. Int J Epidemiol. 2003, 32: 99-105. 10.1093/ije/dyg007.View ArticlePubMedGoogle Scholar
- Studahl A, Andersson Y: Risk factors for indigenous Campylobacter infection: a Swedish case-control study. Epidemiol Infect. 2000, 125: 269-275. 10.1017/S0950268899004562.View ArticlePubMedPubMed CentralGoogle Scholar
- Unicomb LE, Dalton CB, Gilbert GL, Becker NG, Patel MS: Age-specific risk factors for sporadic Campylobacter infection in regional Australia. Foodborne Pathog Dis. 2008, 5: 79-85. 10.1089/fpd.2007.0047.View ArticlePubMedGoogle Scholar
- Fullerton KE, Ingram LA, Jones TF, Anderson BJ, McCarthy PV, Hurd S, Shiferaw B, Vugia D, Haubert N, Hayes T, et al: Sporadic Campylobacter infection in infants: a population-based surveillance case-control study. Pediatr Infect Dis J. 2007, 26: 19-24. 10.1097/01.inf.0000247137.43495.34.View ArticlePubMedGoogle Scholar
- Thompson JS, Cahoon FE, Hodge DS: Rate of Campylobacter spp. isolation in three regions of Ontario, Canada, from 1978 to 1985. J Clin Microbiol. 1986, 24: 876-878.PubMedPubMed CentralGoogle Scholar
- Ogden ID, Dallas JF, MacRae M, Rotariu O, Reay KW, Leitch M, Thomson AP, Sheppard SK, Maiden M, Forbes KJ, Strachan NJ: Campylobacter excreted into the environment by animal sources: prevalence, concentration shed, and host association. Foodborne Pathog Dis. 2009, 6: 1161-1170. 10.1089/fpd.2009.0327.View ArticlePubMedPubMed CentralGoogle Scholar
- Gillespie IA, O'Brien SJ, Frost JA, Tam C, Tompkins D, Neal KR, Syed Q, Farthing MJ: Investigating vomiting and/or bloody diarrhoea in Campylobacter jejuni infection. J Med Microbiol. 2006, 55: 741-746. 10.1099/jmm.0.46422-0.View ArticlePubMedGoogle Scholar
- Blaser MJ, Allos BM: Campylobacter jejuni and related species. Mandell, Douglas, and Bennett's: Principles and Practice of Infectious Diseases. Edited by: Mandell GL, Bennett JE, Dolin R. 2005, Philadelphia, Pennsylvania: Elsevier Inc, 2548-2555. 6Google Scholar
- Butzler JP: Campylobacteriosis in humans (A historical overview). The Increasing Incidence of Human Campylobacteriosis Report and Proceedings of a WHO Consultation of Experts. 2000, Copenhagen, Denmark: Department of Communicable Disease Surveillance and Response, 38-41.Google Scholar
- Health Canada (Division of Foodborne and Enteric Diseases): Canadian Integrated Surveillance Report for 1995 on Salmonella, Campylobacter and Pathogenic Escherichia coli. Can Commun Dis Rep. 1998, 24S5:Google Scholar
- Cook RJ, Lawless JF: The Statistical Analysis of Recurrent Events. 2007, New York: SpringerGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://0-www.biomedcentral.com.brum.beds.ac.uk/1471-2458/11/32/prepub
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