Skip to main content

Table 2 Univariate and multivariable regression analyses

From: Maternal characteristics during pregnancy and risk factors for positive HIV RNA at delivery: a single-cohort observational study (Brescia, Northern Italy)

Patient characteristics N = 93

Risk ratio for detectable HIV-RNA at delivery (95% confidence interval); p-value

 

Patients with undetectable HIV-RNA at delivery N = 68

Patients with detectable HIV-RNA at delivery N = 25

Univariate analyses

Multivariable regression analyses using generalized linear models

Nationality (N, %)

    

Italian

32/39 (82.1%)

7/39 (17.9%)

Ref.

Excluded due to collinearity with cART

Non-Italian

36/54 (66.7%)

18/54 (33.3%)

1.86 (0.86- 4.01); p = 0.099

 

Age (mean years, SD)

31.5 (5.5)

30.5 (4.99)

For each year 0.98 (0.93-1.04); p = 0.5

For each year 0.99 (0.94-1.05); p = 0.9

Calendar year at pregnancy (mean, SD)

2005.8 (1.6)

2005.6 (1.3)

For each year 0.93 (0.76-1.15); p = 0.7

For each year 0.96 (0.85-1.10); p = 0.6

cART at HIV RNA test (N, %)

    

   0 drugs

1/9 (11%)

8/9 (89%)

4.4 (2.7-7.1); p < 0.0001

Dichotomy variable (no cART - versus- any cART)

   2 drugs

6/6 (100%)

0/6 (0%)

  

   ≥3 drugs

61/78 (78%)

17/78 (22%)

Ref. 2 or ≥3 drugs (no differences among the 2)

4.4 (2.7-7.2) P < 0.0001

cART relative to pregnancy (N, %)

    

before 2nd trimester

49/60 (82%)

11/60 (18%)

Ref. any periods (no differences among the 3)

 

2nd trimester

14/19 (74%)

5/19 (26%)

  

3rd trimester

4/5 (80%)

1/5 (20%)

  

No therapy

1/9 (11%)

8/9 (89%)

4.4 (2.7-7.1); P < 0.0001

 

CD4+/mm3 at pregnancy (mean, SD)

468 (223)

376 (204)

For each 50 CD4+/mm3 0.91 (0.84-0.99); P = 0.037

For each 50 CD4+/mm3 0.94 (0.89-0.99); P = 0.032

  1. Analyses were on patients with plasma viral load measured at the time of delivery (within 30 days before delivery). cART: combination antiretroviral therapy; Ref.: reference category.