Instruments | Categories | Variables |
---|---|---|
ADE assessment and investigation questionnaire | ADE occurring features | ADE affected organs; Signs and symptoms; Symptoms first appearing time and their duration; Suspected drugs and their sequencing; Assessment of ADE relationship with anti-TB drugs. |
 | ADE treatment, prognosis | Clinical consultation, treatment, examination and hospitalization induced by ADE; Drugs used; Examinations taken; Days of hospitalization; ADE prognosis. |
 | Direct and indirect costs of ADE | Drug, examination, hospitalization cost; Transport, nutrition, nursing fees; missing working time of patients and family; Impaction on anti-TB treatment such as drug change, drug withdrawal and costs induced; Percentage of health insurance payment for direct medication expenditure. |
Nested case-control questionnaire | TB treatment surveillance | Patient's drug taken compliance in latest 1 month; Drug taken timing; Supervising doctor's visiting times; Health education given to patient. |
 | Lifestyle risk factors | Smoking; drinking; Intake of milk, tea and other diet habits, etc. |
 | Knowledge and faith | Patient's knowledge of TB curing, spreading, ADRs, etc; Patient's Faith in curing TB with current treatment. |
Tuberculosis outcome record | Performance in the end of initial intensive phase of treatment | Whether patient's serum smear turns to be Mycobacterium negative. Whether a prolongation of initial intensive phase is needed. |
 | Time and reason for ending anti-TB therapy | Reasons: curing, exceeding 6-9 months, death form TB, death from other reasons, treatment failure, lost, outmigration, refusing treatment, misdiagnosis, or others. |
ADACS follow up calendar | Discomforts | Everyday record of discomforting such as nausea, vertigo, headache, diarrhea, arthralgia, paresthesia, visual and auditory abnormal feelings. |
 | Anti-TB drug usage | Everyday record of usage of anti-TB drug. |
Genotyping result | Candidate genes | N-acetyltransferase 2(NAT2); Cytochrome P450 2E1 (CYP2E1); Glutathione S-transferase (GST) enzyme(GSTM1, GSTT1), etc. |