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Table 5 Health impact of alternative scale-up scenarios in the GAVI-eligible countries

From: Health and economic impact of rotavirus vaccination in GAVI-eligible countries

No

Scale-up scenarios

No. of children vaccinated

(in million)

No. of outpatient visits averted

(r = 0%) (in million)

No. of hospitalization averted

(r = 0%) (in million)

No. of deaths averted

(r = 0%) (in million)

YL saved

(r = 3%) (in million)

DALYs averted

(r = 3%) (in million)

1

Base-case rollout scenario (Table 2)

      
 

Vaccine efficacy based on the SAGE approach

      
 

Vaccine immunity waning (14% annually)

281.8

40.7

4.5

0.9

20.3

20.4

2

Base-case rollout scenario (Table 2)

      
 

Vaccine efficacy based on the SAGE approach

      
 

No vaccine immunity waning

281.8

44.1

4.9

1.0

22.0

22.1

3

Base-case rollout scenario (Table 2)

      
 

Vaccine efficacy adjusted for serotype distribution

      
 

Vaccine immunity waning (14% annually)

281.8

47.8

5.6

1.2

25.3

25.4

4a

Base-case rollout scenario (Table 2)

      
 

Vaccine efficacy adjusted for serotype distribution

      
 

No vaccine immunity waning

281.8

51.7

6.0

1.3

27.3

27.4

5

(Modified) Wolfson et al. scenario [37]

      
 

Vaccine efficacy based on the SAGE approach

      
 

No vaccine immunity waning

410.5

64.2

7.7

1.6

35.6

35.7

6

(Modified) Wolfson et al. scenario [37]

      
 

Vaccine efficacy adjusted for serotype distribution

      
 

No vaccine immunity waning

410.5

81.4

10.4

2.2

48.1

48.3

7

A flat coverage of 70%

      
 

Vaccine efficacy based on the SAGE approach

      
 

No vaccine immunity waning

537.0

85.9

10.1

2.1

48.9

49.1

8

A flat coverage of 70%

      
 

Vaccine efficacy adjusted for serotype distribution

      
 

No vaccine immunity waning

537.0

106.6

13.3

2.8

64.5

64.7

  1. r = discount rate; YL = years of life; DALYs = disability-adjusted life-years; I$ = international dollars; SAGE = Strategic Advisory Group of Experts on Immunization.
  2. a Base-case analysis.